biophysicalThe development and application of measurement tools to elucidate the functional properties of biological macromolecules and map the distribution of active biomolecules in both organisms and the environment are areas of strength in the department.

Bioanalytical faculty members (Beckett, Blough, Dayie, Fenselau, Fushman, Herzberg, Kahn, Lee, LaRonde, Lorimer, Nie, Orban, Paukstelis, Weeks ) utilize a range of nano-, micro- and macro-techniques to quantitate, identify and manipulate biomolecules in both environmental and biological systems. In the Biophysical Area, research laboratories apply an array of biophysical techniques and approaches including fluorescence spectroscopy, rapid kinetics, analytical ultracentrifugation, ITC, NMR and computation to reveal the mechanistic properties of biomolecules . Among the systems studied include RNA and DNA structure and dynamics, protein:protein interactions in cell signaling and bacterial pathogenesis, and development of nucleic acid nanostructures.

Bioanalytical and Biophysical Chemistry research in the department is enhanced by close ties and collaborations with the Maryland Biophysics Program, the Maryland Nanocenter, the National Institutes of Standards and Technology , the University of Maryland, Baltimore, and the Institute for Biosciences and Biotechnology Research (IBBR).


Photo of Dorothy Beckett

Dorothy Beckett

Biological regulation; allostery; protein:protein interactions; transcription regulation, bacterial virulence; thermodynamics; kinetics; structural biology; computational biologyRead More

Biological regulation; allostery; protein:protein interactions; transcription regulation, bacterial virulence; thermodynamics; kinetics; structural biology; computational biology

Photo of Neil Blough

Neil Blough

Photochemical and free radical reactions in condensed phases; development of molecular probes to examine these reactions in biological and environmental systems; optical properties and the remote sensing of seawater constituents

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Photochemical and free radical reactions in condensed phases; development of molecular probes to examine these reactions in biological and environmental systems; optical properties and the remote sensing of seawater constituents

Photo of Kwaku Dayie

Kwaku Dayie

Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.

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Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.

Photo of Catherine Fenselau

Catherine Fenselau

Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancerRead More

Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancer

Photo of David Fushman

David Fushman

Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biology

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Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biology

Photo of Osnat Herzberg

Osnat Herzberg

Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitorsRead More

Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitors

Photo of Jason Kahn

Jason Kahn

Biophysical chemistry; DNA structure, flexibility, and topology in multi-protein DNA complexes and DNA loops; transcription and gene regulation; DNA and RNA packaging by peptides used for transfection; protein-DNA nanostructures; thermodynamics of modified DNARead More

Biophysical chemistry; DNA structure, flexibility, and topology in multi-protein DNA complexes and DNA loops; transcription and gene regulation; DNA and RNA packaging by peptides used for transfection; protein-DNA nanostructures; thermodynamics of modified DNA

Photo of Nicole LaRonde

Nicole LaRonde

Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and development

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Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and development

Photo of Cheng Lee

Cheng Lee

Bioseparation; capillary electrophoresis/liquid chromatography-mass spectrometry; microfluids and microfabricated devices; drug screening and monitoring; proteome characterization

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Bioseparation; capillary electrophoresis/liquid chromatography-mass spectrometry; microfluids and microfabricated devices; drug screening and monitoring; proteome characterization

Photo of George Lorimer

George Lorimer

Biophysical chemistry, enzyme mechanisms, protein folding

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Biophysical chemistry, enzyme mechanisms, protein folding

Photo of John Orban

John Orban

Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomics

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Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomics

Photo of Paul Paukstelis

Paul Paukstelis

Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.Read More

Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.

Photo of John Weeks

John Weeks

Statistical mechanics of interfaces; theory of crystal growth; theory of nonuniform liquids; dynamics of steps on crystal surfaces

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Statistical mechanics of interfaces; theory of crystal growth; theory of nonuniform liquids; dynamics of steps on crystal surfaces

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