Principal Investigators are faculty who direct major research programs and supervise the training of graduate and undergraduate students in their research laboratories.


Photo of Millard Alexander

Millard Alexander

Dynamics of reactive and inelastic collisions involving open-shell atoms and small molecules; rotational, vibrational, and electronic energy transfer, photodissociation and photo-detachment of small systems; algorithm development for the quantum study of collisional dynamics.

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Dynamics of reactive and inelastic collisions involving open-shell atoms and small molecules; rotational, vibrational, and electronic energy transfer, photodissociation and photo-detachment of small systems; algorithm development for the quantum study of collisional dynamics.

Photo of Dorothy Beckett

Dorothy Beckett

Biological regulation; allostery; protein:protein interactions; transcription regulation, bacterial virulence; thermodynamics; kinetics; structural biology; computational biologyRead More

Biological regulation; allostery; protein:protein interactions; transcription regulation, bacterial virulence; thermodynamics; kinetics; structural biology; computational biology

Photo of Neil Blough

Neil Blough

Photochemical and free radical reactions in condensed phases; development of molecular probes to examine these reactions in biological and environmental systems; optical properties and the remote sensing of seawater constituents

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Photochemical and free radical reactions in condensed phases; development of molecular probes to examine these reactions in biological and environmental systems; optical properties and the remote sensing of seawater constituents

Photo of Marco Colombini

Marco Colombini

Self-assembly of lipids into large, stable nanopores; regulation of lipid nanopores by proteins; dynamics of lipid nanopores; cooperativity and voltage gating in protein channelsRead More

Self-assembly of lipids into large, stable nanopores; regulation of lipid nanopores by proteins; dynamics of lipid nanopores; cooperativity and voltage gating in protein channels

Photo of Jeffery Davis

Jeffery Davis

Supramolecular chemistry; bioorganic chemistry; molecular self-assembly; chemical synthesis and chemistry of bioconjugates; transmembrane ion transport

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Supramolecular chemistry; bioorganic chemistry; molecular self-assembly; chemical synthesis and chemistry of bioconjugates; transmembrane ion transport

Photo of Kwaku Dayie

Kwaku Dayie

Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.

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Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.

Photo of Philip DeShong

Philip DeShong

Bioconjugate Chemistry; Colloid Chemistry; Nanotechnology. Synthesis of complex bioconjugates; Functionalized nanomaterials for use as biosensors, drug delivery, and vaccine development.Read More

Bioconjugate Chemistry; Colloid Chemistry; Nanotechnology. Synthesis of complex bioconjugates; Functionalized nanomaterials for use as biosensors, drug delivery, and vaccine development.

Photo of Russell Dickerson

Russell Dickerson

Atmospheric chemistry; photochemistry and global biogeochemical cycles; development of analytical instruments for quantitation of atmospheric gases and chemical actinometry (for photolysis rate measurements); laboratory, field, and on-aircraft measurements

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Atmospheric chemistry; photochemistry and global biogeochemical cycles; development of analytical instruments for quantitation of atmospheric gases and chemical actinometry (for photolysis rate measurements); laboratory, field, and on-aircraft measurements

Photo of Jonathan Dinman

Jonathan Dinman

My laboratory studies three distinct yet overlapping fields of study: virology, ribosome structure/function relationships, and regulation of gene expression.Read More

My laboratory studies three distinct yet overlapping fields of study: virology, ribosome structure/function relationships, and regulation of gene expression.

Photo of Bryan Eichhorn

Bryan Eichhorn

Synthesis and characterization of transition metal derivatives of Zintl ions; nanomaterials, soft chemical synthesis; heterogeneous catalysis and solid oxide fuel cell research

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Synthesis and characterization of transition metal derivatives of Zintl ions; nanomaterials, soft chemical synthesis; heterogeneous catalysis and solid oxide fuel cell research

Photo of Daniel Falvey

Daniel Falvey

Organic Photochemistry; ultrafast laser spectroscopy studies of the dynamics of organic and enzymatic reactions; biophysical chemistry; photothermal methods; UV-damage and repair of DNA

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Organic Photochemistry; ultrafast laser spectroscopy studies of the dynamics of organic and enzymatic reactions; biophysical chemistry; photothermal methods; UV-damage and repair of DNA

Photo of Catherine Fenselau

Catherine Fenselau

Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancerRead More

Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancer

Photo of John T. Fourkas

John T. Fourkas

Nanotechnology and ultrafast nonlinear optics; multiphoton absorption polymerization; polymer post-functionalization chemistry; soft nanolithography; optical data storage; nanophotonics; microsensors; ultrafast dynamics of liquids in the bulk and in nanoconfinement

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Nanotechnology and ultrafast nonlinear optics; multiphoton absorption polymerization; polymer post-functionalization chemistry; soft nanolithography; optical data storage; nanophotonics; microsensors; ultrafast dynamics of liquids in the bulk and in nanoconfinement

Photo of David Fushman

David Fushman

Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biology

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Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biology

Photo of Osvaldo Gutierrez

Osvaldo Gutierrez

Computational catalyst design; concerted use of computation and experiment to elucidate reaction mechanisms and origins of selectivity in dual transition metal/photoredox-catalyzed transformations; reactive intermediates in iron-catalysisRead More

Computational catalyst design; concerted use of computation and experiment to elucidate reaction mechanisms and origins of selectivity in dual transition metal/photoredox-catalyzed transformations; reactive intermediates in iron-catalysis

Photo of Osnat Herzberg

Osnat Herzberg

Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitorsRead More

Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitors

Photo of Lyle Isaacs

Lyle Isaacs

Host-guest chemistry; molecular recognition; drug delivery; cucurbituril molecular containers;

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Host-guest chemistry; molecular recognition; drug delivery; cucurbituril molecular containers;

Photo of Christopher Jarzynski

Christopher Jarzynski

Equilibrium and non-equilibrium statistical mechanics; solvation phenomena; numerical estimation of thermodynamic properties; biological and artificial molecular machines; control of nanoscale systems

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Equilibrium and non-equilibrium statistical mechanics; solvation phenomena; numerical estimation of thermodynamic properties; biological and artificial molecular machines; control of nanoscale systems

Photo of Douglas Julin

Douglas Julin

Enzymology and mechanisms of DNA recombination and repair; mechanism of the RecBCD enzyme from E. coli. DNA repair in Deinococcus radiodurans

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Enzymology and mechanisms of DNA recombination and repair; mechanism of the RecBCD enzyme from E. coli. DNA repair in Deinococcus radiodurans

Photo of Jason Kahn

Jason Kahn

Biophysical chemistry; DNA structure, flexibility, and topology in multi-protein DNA complexes and DNA loops; transcription and gene regulation; DNA and RNA packaging by peptides used for transfection; protein-DNA nanostructures; thermodynamics of modified DNARead More

Biophysical chemistry; DNA structure, flexibility, and topology in multi-protein DNA complexes and DNA loops; transcription and gene regulation; DNA and RNA packaging by peptides used for transfection; protein-DNA nanostructures; thermodynamics of modified DNA

Photo of Nicole LaRonde

Nicole LaRonde

Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and development

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Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and development

Photo of Cheng Lee

Cheng Lee

Bioseparation; capillary electrophoresis/liquid chromatography-mass spectrometry; microfluids and microfabricated devices; drug screening and monitoring; proteome characterization

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Bioseparation; capillary electrophoresis/liquid chromatography-mass spectrometry; microfluids and microfabricated devices; drug screening and monitoring; proteome characterization

Photo of Sang Bok Lee

Sang Bok Lee

Nanomaterials science; synthesis and characterization of bio-nanotubes for nanotoxicology and biomedical applications; electrical energy storage; electrochemistryRead More

Nanomaterials science; synthesis and characterization of bio-nanotubes for nanotoxicology and biomedical applications; electrical energy storage; electrochemistry

Photo of George Lorimer

George Lorimer

Biophysical chemistry, enzyme mechanisms, protein folding

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Biophysical chemistry, enzyme mechanisms, protein folding

Photo of William F. McDonough

William F. McDonough

Solid earth geochemistry, cosmochemistry including elemental and isotopic studies, development of instrumentation and applications

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Solid earth geochemistry, cosmochemistry including elemental and isotopic studies, development of instrumentation and applications

Photo of Alice Mignerey

Alice Mignerey

Relativistic and ultra-relativistic heavy-ion-induced nuclear reactions, part of the Phobos experiment at the Brookhaven National Laboratory RHIC; application of accelerator mass spectrometry to environmental problems

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Relativistic and ultra-relativistic heavy-ion-induced nuclear reactions, part of the Phobos experiment at the Brookhaven National Laboratory RHIC; application of accelerator mass spectrometry to environmental problems

Photo of Amy Mullin

Amy Mullin

Reactivity and dynamics of high energy molecules; molecules in strong fields; molecular collisions; surface-enhanced spectroscopy; high-resolution time-resolved laser probes

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Reactivity and dynamics of high energy molecules; molecules in strong fields; molecular collisions; surface-enhanced spectroscopy; high-resolution time-resolved laser probes

Photo of Zhihong Nie

Zhihong Nie

Nanoparticle chemistry and self-assembly; soft materials, microfluidic mimicking of biological tubules for studying pharmacokinetics and diseases; biomimetic programmable soft materials for tunable optics and tissue engineering

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Nanoparticle chemistry and self-assembly; soft materials, microfluidic mimicking of biological tubules for studying pharmacokinetics and diseases; biomimetic programmable soft materials for tunable optics and tissue engineering

Photo of John Ondov

John Ondov

Measurements of sub-micrometer aerosol particles; particulate tracer science; particle deposition; tracers of atmospheric particles; development of semi-continuous monitor for airborne metals; nuclear analytical methods and nuclear forensics; radiocarbon analyses of single compounds

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Measurements of sub-micrometer aerosol particles; particulate tracer science; particle deposition; tracers of atmospheric particles; development of semi-continuous monitor for airborne metals; nuclear analytical methods and nuclear forensics; radiocarbon analyses of single compounds

Photo of John Orban

John Orban

Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomics

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Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomics

Photo of Garyk Papoian

Garyk Papoian

Advanced computational methods to study biological systems; histones, nucleosomes and chromatin folding; actin-based cytoskeletal self-assembly and mechanochemistry; protein folding and dynamics; development of algorithms and publicly-released software for modeling biomolecules and cellular processes.Read More

Advanced computational methods to study biological systems; histones, nucleosomes and chromatin folding; actin-based cytoskeletal self-assembly and mechanochemistry; protein folding and dynamics; development of algorithms and publicly-released software for modeling biomolecules and cellular processes.

Photo of Paul Paukstelis

Paul Paukstelis

Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.Read More

Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.

Photo of Myles B. Poulin

Myles B. Poulin

Bioorganic chemistry, enzymology, carbohydrate chemistry, glycobiology, molecular biology, microbiology, bacterial biofilm biosynthesis, membrane transport of polysaccharides, kinetic isotope effectsRead More

Bioorganic chemistry, enzymology, carbohydrate chemistry, glycobiology, molecular biology, microbiology, bacterial biofilm biosynthesis, membrane transport of polysaccharides, kinetic isotope effects

Photo of Srinivasa R. Raghavan

Srinivasa R. Raghavan

Self- and directed assembly of matter  at the nano-micro scales; tailored rheology (viscosity) or soft matter;  biomolecular and biomimetic structures; smart fluids and ; applications in  oil recovery, drug delivery, wound healing, and energy storage

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Self- and directed assembly of matter  at the nano-micro scales; tailored rheology (viscosity) or soft matter;  biomolecular and biomimetic structures; smart fluids and ; applications in  oil recovery, drug delivery, wound healing, and energy storage

Photo of Janice Reutt-Robey

Janice Reutt-Robey

Surface chemistry and interface science: nanostructured materials for energy science and chemical sensing; charge and mass transfer dynamics; scan probe microscopy and spectroscopy; aerosol molecular beam deposition; film growth

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Surface chemistry and interface science: nanostructured materials for energy science and chemical sensing; charge and mass transfer dynamics; scan probe microscopy and spectroscopy; aerosol molecular beam deposition; film growth

Photo of Efrain Rodriguez

Efrain Rodriguez

Inorganic materials and solid state chemistry; synthesis of transition metal (TM) oxides chalcogenides and pnictides;  metastable materials; functional magnetic, electronic, and mixed-conductivity materials;  X-ray and neutron diffraction ; magnetoelectrical transport

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Inorganic materials and solid state chemistry; synthesis of transition metal (TM) oxides chalcogenides and pnictides;  metastable materials; functional magnetic, electronic, and mixed-conductivity materials;  X-ray and neutron diffraction ; magnetoelectrical transport

Photo of Ross Salawitch

Ross Salawitch

Computer modeling of the effects of human activity on atmospheric composition with an emphasis on ozone depletion, air quality, climate change, and the global carbon cycle

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Computer modeling of the effects of human activity on atmospheric composition with an emphasis on ozone depletion, air quality, climate change, and the global carbon cycle

Photo of Lawrence R. Sita

Lawrence R. Sita

Synthetic, structural and mechanistic inorganic and organometallic chemistry; molecular and mesoscopic self-assembly processes; chemically modified surface and interfaces, polymer synthesis, development and utilization of low cost catalysts for commodity chemical production

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Synthetic, structural and mechanistic inorganic and organometallic chemistry; molecular and mesoscopic self-assembly processes; chemically modified surface and interfaces, polymer synthesis, development and utilization of low cost catalysts for commodity chemical production

Photo of Andrei Vedernikov

Andrei Vedernikov

Experimental and computational organotransition metal chemistry; homogeneous catalysis pursuing the development of green synthetic methodologies; hydrocarbon transformations, methane conversion to value-added chemicals

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Experimental and computational organotransition metal chemistry; homogeneous catalysis pursuing the development of green synthetic methodologies; hydrocarbon transformations, methane conversion to value-added chemicals

Photo of William Walters

William Walters

Production mechanism and decay of short-lived radioactive isotopes; on-line isotope separations and nuclear orientation; analytical neutron-capture gamma-ray spectroscopy; nucleosynthesis

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Production mechanism and decay of short-lived radioactive isotopes; on-line isotope separations and nuclear orientation; analytical neutron-capture gamma-ray spectroscopy; nucleosynthesis

Photo of Lai-Xi Wang

Lai-Xi Wang

Bioorganic chemistry;  chemical biology; synthetic carbohydrate chemistry; glycobiology; enzymology; molecular biology; immunology; chemoenzymatic synthesis of oligosaccharides and glycoproteins; protein glycosylation; antibody glycoengineering; HIV vaccine designRead More

Bioorganic chemistry;  chemical biology; synthetic carbohydrate chemistry; glycobiology; enzymology; molecular biology; immunology; chemoenzymatic synthesis of oligosaccharides and glycoproteins; protein glycosylation; antibody glycoengineering; HIV vaccine design

Photo of Yu-Huang Wang

Yu-Huang Wang

Carbon nanotechnology; scanning probe lithography; directed assembly of nanoscale building blocks; new chemistries and physics based on nanostructured materials with implications to energy, electronics and biomedicine

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Carbon nanotechnology; scanning probe lithography; directed assembly of nanoscale building blocks; new chemistries and physics based on nanostructured materials with implications to energy, electronics and biomedicine

Photo of John Weeks

John Weeks

Statistical mechanics of interfaces; theory of crystal growth; theory of nonuniform liquids; dynamics of steps on crystal surfaces

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Statistical mechanics of interfaces; theory of crystal growth; theory of nonuniform liquids; dynamics of steps on crystal surfaces

Photo of Wade Winkler

Wade Winkler

Metal Ion Homeostasis, Antitermination, RNA Binding Proteins, Noncoding RNAs, Ribozymes

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Metal Ion Homeostasis, Antitermination, RNA Binding Proteins, Noncoding RNAs, Ribozymes

Photo of Michael Zachariah

Michael Zachariah

Aerosol nanoparticle physics and chemistry; nanostructured materials; development of chemical and physical characterization for nanoparticles; nanomaterials in energy applications

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Aerosol nanoparticle physics and chemistry; nanostructured materials; development of chemical and physical characterization for nanoparticles; nanomaterials in energy applications

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