struc_biologyThe Department of Chemistry and Biochemistry at the University of Maryland has exceptional strength in structural biology, with research focusing on the elucidation at atomic-level resolution of the structures, dynamics, and interactions of proteins and nucleic acids of key importance to cellular function and on the development of novel methods and approaches to characterize these systems. Studies in this area are performed at the interface between chemistry, biology and physics and span a wide range of problems at the forefront of biological research.

The faculty members with interests in structural biology (BeckettDayie, Fenselau, Fushman, Herzberg, LaRonde, Lorimer, Orban, Paukstelis) are international leaders in  their subdisciplines. Their contributions to science have been recognized by major professional awards, including the Joel Hildebrand Prize and the Field and Franklin Award of the American Chemical Society, the Thomson Medal from the International Mass Spectrometry Foundation and the Alexander von Humboldt Research Prize. George Lorimer is a member of the National Academy of Sciences and a fellow of the Royal Society of London.

At the University of Maryland, we are part of an environment designed for discovery and innovation in the biochemical and biophysical sciences. Collaborative ties that fuel interdisciplinary research are nurtured, including interaction with other departments or institutes, such as  the Institute for Biosciences and Biotechnology Research (IBBR), the Institute for Physical Science and Technology (IPST), Department of Cell Biology and Molecular Genetics (CBMG) , Fischel Department of Bioengineering, the University of Maryland Marlene and Stewart Greenebaum Cancer Center, and the Institute for Human Virology (IHV).


Photo of Kwaku Dayie

Kwaku Dayie

Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.

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Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.

Photo of Catherine Fenselau

Catherine Fenselau

Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancerRead More

Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancer

Photo of David Fushman

David Fushman

Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biology

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Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biology

Photo of Osnat Herzberg

Osnat Herzberg

Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitorsRead More

Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitors

Photo of Nicole LaRonde

Nicole LaRonde

Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and development

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Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and development

Photo of John Orban

John Orban

Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomics

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Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomics

Photo of Paul Paukstelis

Paul Paukstelis

Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.Read More

Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.

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