Biography

Wang


CONTACT INFORMATION

Office Phone:301 405-7527
Office Address: 3500A
 Email: wang518@umd.edu
Group Website

Professor

Education

  • Ph.D., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 1991
  • Postdoctoral Fellow, Johns Hopkins University, 1994
  • Postdoctoral Research Associate, Massachusetts Institute of Technology, 1997

Professional Experience

  • Professor, Department of Chemistry and Biochemistry, University of Maryland, College Park, 2015 –
  • Professor, Institute of Human Virology, University of Maryland School of Medicine, 2009-2014
  • Professor, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, 2009-2014
  • Associate Professor, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, 2007-2009
  • Associate Professor, Institute of Human Virology, University of Maryland School of Medicine, 2005-2009
  • Assistant Professor, Institute of Human Virology, University of Maryland, 2000-2005
  • Postdoctoral Research Associate, Massachusetts Institute of Technology, 1997-2000
  • Postdoctoral Fellow, Johns Hopkins University, 1994-1997
  • Faculty Member (Assistant Professor 1991-1992; Associate Professor, 1992-1993), Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 1991-1993

Research Interests

Bioorganic Chemistry; Synthetic Carbohydrate Chemistry; Glycobiology; Enzymology; Molecular Biology; Immunology

Professional Societies

American Chemical Society; American Association for the Advancement of Science

Major Recognitions and Honors

  • The Melville L. Wolfrom Award in Carbohydrate Chemistry, American Chemical Society, 2014
  • Elected Vice Chair and Chair for the 2015 and 2017 Carbohydrate Gordon Research Conference (GRC), 2013
  • Inducted to the Johns Hopkins University Society of Scholars, 2009
  • Young Investigator Award in Carbohydrate Chemistry, Division of Carbohydrate Chemistry, American Chemical Society, 2004
  • Predoctoral Scholarship, the Institute of Physical & Chemical Research (RIKEN), Wako-Shi, Saitama, Japan, 1988-1991

Significant Professional Service and Activities

  • Member, NIH BCMB Special Emphasis Panel, 2013
  • Chartered Member, NIH Synthetic and Biological Chemistry (SBCA) Study Section, 2008-2012
  • Member, Faculty of 1000 (F1000), Chemical Biology, 2012 – present
  • Member-At-Large, Executive Committee, ACS Carbohydrate Division, 2010-2013
  • Member, the Editorial Board, Carbohydrate Research, 2009 – present
  • Member, Greenebaum Cancer Center, University of Maryland,, 2007 – present
  • Member, NIH BCMB Special Emphasis Panel, 2006-2007
  • Ad hoc Member, Synthetic and Biological Chemistry (SBCA) Study Section, NIH, 2005-2007
  • Faculty Senator, University of Maryland Biotechnology Institute, 2001-2003
  • Co-Director, Baltimore-Washington DC Area Glycobiology Interesting Group (BWGIG, formerly JHUGIG), 2010 – present
  • Co-Organizer, symposium on “Synthetic Oligosaccharides and Glycoconjugates for Preventing and Combating Diseases”. the 240th ACS annual meeting, August 22-26, Boston, MA, 2010
  • Co-Organizer, symposium on “Carbohydrate-Mediated Host-Pathogen Interactions and Their Interventions”. the 243rd ACS annual meeting, March 25-29, San Diego, CA, 2012
  • Organizer, symposium on “Carbohydrates in Drug Discovery”. The 43rd ACS MARM meeting, June 2, Baltimore, MA, 2012

Students Mentored

Dr. Wang has mentored 22 postdoctoral fellows, 5 Ph.D. graduate students, and 5 undergraduate students for their research

Selected Publications

Research

The Wang Lab is working at the interface of chemistry, biology, and immunology with a focus on the structures and functions of glycans and glycoproteins. Glycosylation is one of the most ubiquitous posttranslational modifications of proteins in eukaryotes. The covalent attachment of glycans adds a new level of structural and functional diversity of proteins and expands the biological information of an otherwise concise human genome. Students and postdoctoral researchers in the Wang group explore tools and concepts from various fields including synthetic organic chemistry, molecular biology, structural biology and immunology to understand the functional roles of glycans and glycoproteins in biological systems (host-pathogen interactions, symbiosis, and other important biological recognition processes). The group is also interested in translating the knowledge gained from functional and mechanistic studies into the design and development of more efficient therapeutic agents and vaccines against cancer and infectious diseases.

Current Research Projects

1. Chemoenzymatic synthesis of oligosaccharides, glycolipids, and glycoproteins

2. Site-specific glycoengineering and functional studies of antibodies

3. Design, synthesis, and immunological evaluation of carbohydrate-based HIV vaccine

4. Design and synthesis of specific ligands and inhibitors for manipulating the biosynthesis of glycoconjugates in cellular systems

 

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