Biography

Wang


CONTACT INFORMATION

Office Phone:301 405-7527
Office Address: 3500A
 Email: wang518@umd.edu
Group Website

Professor

Education

  • Ph.D., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 1991
  • Postdoctoral Fellow, Johns Hopkins University, 1994
  • Postdoctoral Research Associate, Massachusetts Institute of Technology, 1997

Professional Experience

  • Professor, Department of Chemistry and Biochemistry, University of Maryland, College Park, 2015 –
  • Professor, Institute of Human Virology, University of Maryland School of Medicine, 2009-2014
  • Professor, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, 2009-2014
  • Associate Professor, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, 2007-2009
  • Associate Professor, Institute of Human Virology, University of Maryland School of Medicine, 2005-2009
  • Assistant Professor, Institute of Human Virology, University of Maryland, 2000-2005
  • Postdoctoral Research Associate, Massachusetts Institute of Technology, 1997-2000
  • Postdoctoral Fellow, Johns Hopkins University, 1994-1997
  • Faculty Member (Assistant Professor 1991-1992; Associate Professor, 1992-1993), Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 1991-1993

Research Interests

Bioorganic Chemistry; Synthetic Carbohydrate Chemistry; Glycobiology; Enzymology; Molecular Biology; Immunology

Professional Societies

American Chemical Society; American Association for the Advancement of Science

Major Recognitions and Honors

    • The Dean’s Award of Excellence in Teaching, the College of Computer, Mathematical, and Natural Sciences (CMNS), University of Maryland College Park, 2020
    • ACS Fellow, American Chemical Society, 2019
    • AAAS Fellow, the American Association for the Advancement of Science, 2014
    • Melville L. Wolfrom Award in Carbohydrate Chemistry, American Chemical Society, 2014
    • Inducted to the Johns Hopkins University Society of Scholars, 2009,
    • Young Investigator Award in Carbohydrate Chemistry, Division of Carbohydrate Chemistry, American Chemical Society, 2004
    • Predoctoral Scholarship, the Institute of Physical & Chemical Research (RIKEN), Wako-Shi, Saitama, Japan, 1988-1991

Significant Professional Service and Activities

  • Associate Editor, Carbohydrate Research, 2020
  • Chair-Elect, Chair, and Immediate Past Chair, Division of Carbohydrate Chemistry, The American Chemical Society, 2015-2017
  • Chair, The Gordon Research Conference (GRC) on Carbohydrates, 2017
  • Member, the U.S. Advisory Committee for International Carbohydrate Symposia (ICS), 2016
  • Member, the Scientific Advisory Board, the Canadian Glycomics Network, 2015-present
  • Vice Chair, the Gordon Research Conference on Carbohydrates, Dover, VT, 2015
  • Co-organizer, CELL/CARB joint symposium on “Frontiers in Glycoscience”, 249th ACS National Meeting, Denver, Colorado, 2015
  • Session Chair, NIH workshop on “Explore the frontiers of chemical glycoscience”, Bethesda, MD, 2014
  • Member, NIH site-visit review panel, evaluation on P41 Biomedical Technology Research Resource, University of Georgia, Athens, Georgia, 2014
  • Member, NIH BCMB Special Emphasis Panel, 2013
  • Member, Faculty of 1000 (F1000), Chemical Biology, 2012-present
  • Organizer, symposium on “Carbohydrates in Drug Discovery”. The 43rd ACS Middle Atlantic Regional Meeting (MARM), Baltimore, MA, 2012
  • Co-organizer, symposium on “Carbohydrate-mediated Host-Pathogen Interactions and Their Interventions”. the 243rd ACS annual meeting, March 25-29, San Diego, CA, 2012
  • Session Chair, Interfacing Functional Glycomics with Immunobiology of Infections, Functional Glycomics in HIV Vaccine Design, Bethesda, MD, 2012
  • Member, site-visit review panel, evaluation on Chemical Biology Laboratory, NCI/NIH, 2012
  • Session Chair, NIH/FDA Glycoscience Day Symposium, 2011
  • Co-organizer, symposium on “Synthetic oligosaccharides and glycoconjugates for preventing and combating diseases”. the 240th ACS annual meeting, Boston, MA, 2010
  • Co-Director, Baltimore-Washington DC Area Glycobiology Interesting Group (BWGIG, formerly JHUGIG), 2010 – 2016
  • Member, the Editorial Board, Carbohydrate Research, 2009-2019
  • Chartered Member, NIH Synthetic and Biological Chemistry (SBCA) Study Section, 2008-2012
  • Member, Greenebaum Cancer Center, University of Maryland, 2007 – present
  • Member, NIH BCMB Special Emphasis Panel, 2006-2007
  • Ad hoc Member, NIH Synthetic and Biological Chemistry (SBCA) Study Section, 2005-2007
  • Executive Editor for special issues, Current Pharmaceutical Design, 2004-2007

Students Mentored

Dr. Wang has mentored 25 postdoctoral fellows, 10 Ph.D. graduate students, and 16 undergraduate students for their research.

Selected Publications

1. Chen, X., Shi, M., Tong, X., Kim, H. K., Wang, L. X., Schneewind, O., Missiakas, D., “Glycosylation-dependent opsonophagocytic activity of Staphylococcal protein A antibodies”, Proc. Natl. Acad. Sci. USA., 117, 22992-23000 (2020).

2. Dai, Y., Hartke, R., Li, C., Yang, Q., Liu, J. O., Wang, L. X., “Synthetic fluorinated L-fucose analogs inhibit proliferation of cancer cells and primary endothelial cells”, ACS Chemical Biology, 15, 2662-2672 (2020).

3. Wang, L.X., Tong, X., Li, C., Giddens, J.P., Li, T., “Glycoengineering of antibodies for modulating functions”, Annual Review of Biochemistry, 88, 433-459 (2019).

4. Giddens, J., Lomino, J.V., DiLillo, D.J., Ravetch, J.V., Wang, L.X., “Site-specific chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody”, Proc. Natl. Acad. Sci. USA, 115, 12023-12027 (2018).

5. Li, C. and Wang, L.X., “Chemoenzymatic methods for the synthesis of glycoproteins”, Chemical Reviews, 118, 8359-8413 (2018).

6. Li C, Zhu S, Ma C, and Wang LX, “Designer a1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins”, J. Am. Chem. Soc., 139, 15074-15087 (2017).

7. Li, T., DiLillo, D., Bournazos, S., Giddens, J. P., Ravetch, J. V., Wang, L. X., “Modulating IgG effector functions by Fc glycan engineering”, Proc. Natl. Acad. Sci. USA, 114, 3485-3490 (2017).

8. Cai H, Orwenyo J, Giddens JP, Yang Y, Zhang R, LaBranche CC, Montefiori DC, Wang LX, “Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses”, Cell Chemical Biology, 24, 1513-1522 (2017).

9. Li, T., Tong, X., Yang, Q., Giddens, J.P., Wang, L.X., “Glycosynthase mutants of endoglycosidase S2 show potent transglycosylation activity and remarkably relaxed substrate specificity for antibody glycosylation remodeling”, J. Biol. Chem., 291, 16508-16518 (2016).

10. Yamaguchi, T., Amin, M.N., Toonstra, C., Wang, L.X., “Chemoenzymatic synthesis and receptor binding of mannose-6-phosphate (M6P)-containing glycoprotein ligands reveal unusual structural requirements for M6P receptor recognition”, J. Am. Chem. Soc., 138, 12472-85 (2016).

Research

The Wang Lab is working at the interface of chemistry, biology, and immunology with a focus on the structures and functions of glycans and glycoproteins. Glycosylation is one of the most ubiquitous posttranslational modifications of proteins in eukaryotes. The covalent attachment of glycans adds a new level of structural and functional diversity of proteins and expands the biological information of an otherwise concise human genome. Students and postdoctoral researchers in the Wang group explore tools and concepts from various fields including synthetic organic chemistry, molecular biology, structural biology and immunology to understand the functional roles of glycans and glycoproteins in biological systems (host-pathogen interactions, symbiosis, and other important biological recognition processes). The group is also interested in translating the knowledge gained from functional and mechanistic studies into the design and development of more efficient therapeutic agents and vaccines against cancer and infectious diseases.

Current Research Projects

1. Chemoenzymatic synthesis of oligosaccharides, glycolipids, and glycoproteins

2. Site-specific glycoengineering and functional studies of antibodies

3. Design, synthesis, and immunological evaluation of carbohydrate-based HIV vaccine

4. Design and synthesis of specific ligands and inhibitors for manipulating the biosynthesis of glycoconjugates in cellular systems

 

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