Supramolecular Chemistry, Molecular Recognition, Nanoscience and Nanotechnology, Bioorganic Chemistry
Major Recognitions and Honors
Significant Professional Service and Activities
UMCP Nanotechnology Advisory Board, 2004-present; Royal Society of Chemistry Inaugural Lecturer (2006); Organizer, 9th International Conference on Calixarene Chemistry (2007); Co-Organizer, 8th International Symposium on Macrocyclic and Supramolecular Chemistry (2013).
To date over 30 undergraduates have done research with Prof. Davis. He has also mentored 13 Ph. D. degree recipients and 10 M. S. degree recipients.
DAVIS RESEARCH GROUP
SUPRAMOLECULAR CHEMISTRY, MOLECULAR SELF-ASSEMBLY, FUNCTIONAL NANOSTRUCTURES, TRANSMEMBRANE ION TRANSPORT
We are making functional supramolecular structures via self-assembly.
• Supramolecular Hydrogels from natural products have promise in drug delivery and tissue engineering. We have found that potassium borate templates self-assembly of guanosine into a supramolecular hydrogel. This guanosine-borate (GB) hydrogel is stable in salt water and absorbs cationic dyes and antiviral drugs. We are working to determine the mechanism of formation and the range of applications for these hydrogels (J. Am. Chem. Soc. 2014, 136, 12596 and J. Am. Chem. Soc. 2015, 137, 5819.
Proposed Self-Assembly Mechanism for Hydrogel Formation
• Synthetic Cl – Anion Membrane Transporters. Anion transport across membranes is critical to life. Chloride channels regulate salt and fluid balance in cells. Dysfunction in chloride channels can lead to disease. Cystic fibrosis (CF) is caused by a defect in the protein that moves Cl- out of the cell. Small molecules that facilitate transmembrane transport of Cl- are attractive targets for therapeutic intervention. We have discovered a series of synthetic compounds that function in phospholipid membranes to transport Cl- anion across the bilayer. Some of the compounds appear to function by a channel mechanism, whereas others seem to operate by a carrier mechanism. For recent studies Chemical Communications, 2012, 4432 and Organic & Biomolecular Chemistry, 2014, 12, 7515.