Chemical biology involves the exploration of chemical principles for the study and manipulation of biological systems, as well as the harnessing of biology to advance chemistry. It integrates tools and techniques from different scientific fields to foster the innovations and discoveries at the interface of chemistry, biology, and medicine. The Department of Chemistry and Biochemistry at University of Maryland possesses unique strengths in chemical biology.
The research of our faculty focuses on a wide variety of important areas at the chemistry-biology interface. These include: self-assembly and host-guest systems for molecular recognition; design and synthesis of novel molecular probes for deciphering biological functions; development of special analytical tools for investigating enzymatic reactions; innovative approaches to studying ubiquitination, glycosylation, and other posttranslational modifications; site-specific modification of therapeutic antibodies; structural biology and biophysical chemistry of biopolymers and their complexes; advanced computational models of complex biological systems; functional proteomics and glycomics; and
nanotechnology/nanomaterials for drug delivery and vaccine development. These diverse research activities involve exciting interplays of chemistry, biology, materials science, and medicine. In addition, the chemical biology research in the department is also integrated with other departments and nearby institutions including Department of Cell Biology and Molecular Genetics, Department of Bioengineering, University of Maryland School of Medicine, the National Institutes of Health, the National Institute of Standards and Technology, and the US Food and Drug Administration. This highly integrated program provides a unique platform for training, education, and research collaborations at the chemistry-biology interface.
Biological regulation; allostery; protein:protein interactions; transcription regulation, bacterial virulence; thermodynamics; kinetics; structural biology; computational biology
Supramolecular chemistry; bioorganic chemistry; molecular self-assembly; chemical synthesis and chemistry of bioconjugates; transmembrane ion transportRead More
Supramolecular chemistry; bioorganic chemistry; molecular self-assembly; chemical synthesis and chemistry of bioconjugates; transmembrane ion transport
Structure, interactions, dynamics, and function of RNA complexes involved in catalysis and gene regulation; chemical biological methods of labeling RNAs; NMR methods development.Read More
Organic Photochemistry; ultrafast laser spectroscopy studies of the dynamics of organic and enzymatic reactions; biophysical chemistry; photothermal methods; UV-damage and repair of DNARead More
Organic Photochemistry; ultrafast laser spectroscopy studies of the dynamics of organic and enzymatic reactions; biophysical chemistry; photothermal methods; UV-damage and repair of DNA
Biomedical mass spectrometry and bioanalytical chemistry, bioinformatics, proteomics and glycomics, post-translational modifications, cell surface chemistry, next generation sequencing of small RNAs; cell-cell communications and immunosuppression in cancer
Structure, dynamics, and function of proteins and biological macromolecules, signaling and regulation in multidomain systems; intracellular signaling; ubiquitination; posttranslational modifications; Biological NMR and computational biologyRead More
Structural biology; X-ray crystallography; structural approaches to mechanisms of human diseases; rational design of inhibitors
Host-guest chemistry; molecular recognition; drug delivery; cucurbituril molecular containers;Read More
Host-guest chemistry; molecular recognition; drug delivery; cucurbituril molecular containers;
Enzymology and mechanisms of DNA recombination and repair; mechanism of the RecBCD enzyme from E. coli. DNA repair in Deinococcus radioduransRead More
Biophysical chemistry; DNA structure, flexibility, and topology in multi-protein DNA complexes and DNA loops; transcription and gene regulation; DNA and RNA packaging by peptides used for transfection; protein-DNA nanostructures; thermodynamics of modified DNA
Structural biology; X-ray crystallography; structural and functional studies of proteins involved in ribosome biogenesis; biophysical characterization of secreted mycobacterium virulence proteins; Inhibitor design and developmentRead More
Nanomaterials science; synthesis and characterization of bio-nanotubes for nanotoxicology and biomedical applications; electrical energy storage; electrochemistry
Biophysical chemistry, enzyme mechanisms, protein foldingRead More
Biophysical chemistry, enzyme mechanisms, protein folding
Nanoparticle chemistry and self-assembly; soft materials, microfluidic mimicking of biological tubules for studying pharmacokinetics and diseases; biomimetic programmable soft materials for tunable optics and tissue engineeringRead More
Nanoparticle chemistry and self-assembly; soft materials, microfluidic mimicking of biological tubules for studying pharmacokinetics and diseases; biomimetic programmable soft materials for tunable optics and tissue engineering
Structural biology; NMR methods; protein folding; conformational switching and the evolution of new folds; microbial and eukaryotic structural genomicsRead More
Advanced computational methods to study biological systems; histones, nucleosomes and chromatin folding; actin-based cytoskeletal self-assembly and mechanochemistry; protein folding and dynamics; development of algorithms and publicly-released software for modeling biomolecules and cellular processes.
Nucleic acid structure, function, and catalysis; Structural DNA nanotechnology; DNA crystal design; Non-canonical DNA structures; DNA-based catalysts.
Bioorganic chemistry, enzymology, carbohydrate chemistry, glycobiology, molecular biology, microbiology, bacterial biofilm biosynthesis, membrane transport of polysaccharides, kinetic isotope effects
Bioorganic chemistry; chemical biology; synthetic carbohydrate chemistry; glycobiology; enzymology; molecular biology; immunology; chemoenzymatic synthesis of oligosaccharides and glycoproteins; protein glycosylation; antibody glycoengineering; HIV vaccine design